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Alnylam wins FDA approval for first drug to treat rare kidney disease

Alnylam Pharmaceuticals Inc. scored its third approval from the US Food and Drug Administration in as many years Monday, this time for a medicine to treat a rare disease that affects the kidneys.

The rare disorder — called primary hyperoxaluria type 1 — causes a buildup of oxalate in the body, which when not filtered properly can cause kidney and bladder stones.

The Cambridge biotech’s drug, called lumasiran, has been shown to help lower the oxalate levels of patients with the disease. Lumasiran (brand name Oxlumo) is the first medicine approved to treat the disease in the US for both children and adults.

The drug was approved in Europe last week. Alnylam said on a call with investors Tuesday morning that there are roughly 1,000 to 2,000 patients diagnosed with the disease in the US and Europe.

The medicine will be administered in the form of a shot, with the

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Bomb squad responds to drug bust after police find homemade explosive device

CASS COUNTY, MI – Two adults were arrested in a southwest Michigan drug bust where police found a homemade bomb and a “large amount” of Methamphetamine.

The Cass County Drug Enforcement Team conducted a search warrant Friday, Nov. 20, in the 70000 block of Irving Drive in Ontwa Township, according to a news release issued by the Cass County Sheriff’s Office.

Upon arrival, police detained a 44-year-old man and a 33-year-old woman and began to search the premise, according to the release.

Authorities found an Improvised Explosive Device, or a “homemade bomb,” inside the residence and halted the search until the Berrien County Bomb Squad arrived. Police warned neighbors of the residence so they could vacate the area, the release said.

Police resumed the search after the residence was secured and found a “large amount” of Methamphetamine, Methamphetamine paraphernalia and a firearm, according to the sheriff’s office.

Police arrested a

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Trump attacks big Pharma, announces programs to lower drug prices

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In his third appearance since election night, President Trump talked about his administration’s work to lower the price of prescription drugs through regulations and argued its efforts could save Americans up to 30% in drug costs. He announced two new rules aimed at helping seniors, in particular.

He also announced an end to the unapproved drugs initiative, which the administration says creates artificial monopolies for some older drugs. The president said that his administration would prevent exorbitant raises in drug prices and possibly save Americans billions of dollars.

CBS News campaign reporter LaCrai Mitchell reports that the president also took the time to attack Big Pharma

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Federal authorities execute drug dealer who helped bury victim alive

Terra Haute, Indiana — Orlando Hall got stiffed on a drug deal and went to a Texas apartment looking for the two brothers who took his money. They weren’t home, but their 16-year-old sister was.

Late Thursday, Hall was put to death for abducting and killing the teenager, Lisa Rene. His was the eighth federal execution this year since the Trump administration revived a process that had been used just three times in the past 56 years. A judge’s stay over concerns about the execution drug gave Hall a reprieve, but for less than six hours. After the U.S. Supreme Court overturned the stay, he was put to death just before midnight.

Hall, a changed man in prison according to his lawyers and a church volunteer who had grown close to him, was consoling his family and supporters at the end. “I’m OK,” he said in a final statement, adding,

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Mexico’s president: we didn’t threaten to expel U.S. drug agents over General Cienfuegos arrest

MEXICO CITY (Reuters) – Mexican President Andres Manuel Lopez Obrador on Thursday said his government did not threaten to expel U.S. Drug Enforcement Administration (DEA) agents from Mexico in retaliation for former defense minister Salvador Cienfuegos’ arrest on American soil.

Mexico’s former Defense Minister Salvador Cienfuegos takes the oath before Judge Carol Bagley Amon during a hearing to consider a U.S. government request to drop drug charges, in a courtroom sketch in the Brooklyn borough of New York City, U.S. November 18, 2020. REUTERS/Jane Rosenberg MANDATORY CREDIT REFILE – CORRECTING BOROUGH

A federal judge on Wednesday granted a U.S. government request to drop drug charges against Cienfuegos and return him to Mexico, a move Mexico said would restore trust in the countries’ severely strained security ties.

Multiple U.S. news outlets reported that Mexico had threatened the expulsion of U.S. agents over the diplomatic dispute, but Lopez Obrador rejected these accounts

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Judge to review U.S. request to drop drug case against former Mexican defense minister

NEW YORK (Reuters) – A federal judge was expected to grant a U.S. government request to drop drug charges against former Mexican Defense Minister Salvador Cienfuegos on Wednesday, a move Mexico said would restore trust in severely strained security cooperation ties.



Salvador Cienfuegos Zepeda wearing a suit and hat: FILE PHOTO: Mexico's then Defense Minister General Salvador Cienfuegos Zepeda attends a flag-raising ceremony honouring the victims of the September 1985 and 2017 earthquakes at Zocalo square in Mexico City, Mexico


© Reuters/Daniel Becerril
FILE PHOTO: Mexico’s then Defense Minister General Salvador Cienfuegos Zepeda attends a flag-raising ceremony honouring the victims of the September 1985 and 2017 earthquakes at Zocalo square in Mexico City, Mexico

U.S. District Judge Carol Bagley Amon in Brooklyn, New York is considering the request after Tuesday’s abrupt announcement by U.S. Attorney General William Barr and Mexico Attorney General Alejandro Gertz Manero that the U.S. case would end.

Cienfuegos, 72, had served as Mexico’s defense minister from 2012 to 2018 under former President Enrique Pena Nieto, and the case prompted the current government to threaten a review of agreements allowing U.S. agents to operate in

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Oakland man gets 10 years in ‘open air drug market’ case

OAKLAND — An Oakland man who prosecutors say was part of an “open air” drug and gun market has been sentenced to 10 years in federal prison for convictions related to selling crack and possessing a machine gun, court records show.

Paul Rivera, 28, was sentenced last week by U.S. District Judge Yvonne Gonzalez Rogers, after pleading guilty to the two federal offenses, court records show. Rivera was one of several people arrested and charged in federal court with drug and gun sales, all centering on a home on the 200 block of Makin Road in Oakland.

The home — according to police who secretly installed pole surveillance cameras in the area and used confidential informants to buy drugs — was a market for illicit products that operated 24 hours a day, seven days a week. Prosecutors wrote in a sentencing memo that the sellers would switch shifts and receive

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Attorney General Barr wants to drop U.S. drug case against former Mexican defense minister

Mexico’s then Defense Minister General Salvador Cienfuegos Zepeda attends a flag-raising ceremony honoring the victims of the September 1985 and 2017 earthquakes at Zocalo square in Mexico City, Mexico September 19, 2018.

Daniel Becerril | Reuters

The Justice Department has asked a judge to drop criminal charges against Mexico’s former defense secretary, Gen. Salvador Cienfuegos Zepeda, who had been accused of helping one of Mexico’s drug cartels “operate with impunity” while using the Mexican military to hurt its rivals.

In a joint statement, Attorney General William Barr and Mexican Attorney General Alejandro Gertz Manero said the U.S. had dropped the charges so that Cienfuegos “may be investigated and, if appropriate, charged, under Mexican law.”

“The U.S. Department of Justice … has provided Mexico evidence in this case and commits to continued cooperation, within that framework, to support the investigation by Mexican authorities.

Cienfuegos, who served as defense secretary under then-President

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Cytokinetics heart failure drug succeeds but slightly higher death rate seen

By Deena Beasley

(Reuters) – Cytokinetics Inc on Friday said a pivotal trial of the experimental heart failure drug it is developing with Amgen Inc showed a slightly higher rate of cardiovascular-related death for patients given the medicine compared to those on a placebo.

Details presented at annual meeting of the American Heart Association (AHA) held virtually this year follow the release in October of initial results for the 8,256-patient trial. That announcement said the drug, omecamtiv mecarbil, met its main trial combination goal of reducing the risk of heart related death or need for hospitalization and other urgent care.

The benefit, while deemed statistically significant, was not dramatic, with those events occurring in 37% of trial patients treated with the medicine versus 39.1% of the placebo group.

Researchers said on Friday that 809, or 19.6%, of trial patients treated with omecamtiv mecarbil died, compared with 798, or 19.4%, of

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Amgen, AstraZeneca say experimental asthma drug meets trial goal

FILE PHOTO: The company logo for pharmaceutical company AstraZeneca is displayed on a screen on the floor at the New York Stock Exchange (NYSE) in New York, U.S., April 8, 2019. REUTERS/Brendan McDermid

(Reuters) – Drugmakers Amgen Inc and AstraZeneca Plc said on Tuesday a pivotal trial found that their experimental medication tezepelumab significantly reduced asthma attacks for people with severe forms of the respiratory condition compared to a placebo.

The partners said that the year-long trial met its primary goal in patients with severe asthma who were also receiving standard care, including medium- or high-dose inhaled corticosteroids plus at least one other controller medication.

The drug was also shown to work in a subgroup of patients with low levels of a type of white blood cell, called eosinophil, associated with swelling and narrowing of airways, the drugmakers said in a press release.

“The key thing is that tezepelumab also

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